Validation of ion channel targets
نویسندگان
چکیده
منابع مشابه
Antibody-based Validation of CNS Ion Channel Drug Targets
Target validation and selection are critical early steps in the drug discovery process as they trigger substantial activity and investment to identify potential drug candidates. Antibodies play a crucial role in target selection as they provide powerful tools to explore the distribution and subcellular location of candidate molecules and can also be used to explore function. For studies of ion ...
متن کاملErratum: Laser-Driven Ion Acceleration from Plasma Micro-Channel Targets
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متن کاملCell-based assays and instrumentation for screening ion-channel targets.
Ion channels are an important class of drug targets. They comprise the molecular basis for essential physiological functions including fluid secretion, electrolyte balance, bioenergetics and membrane excitability. High-throughput screening for ion-channel function requires sensitive, simple assays and instrumentation that will report ion channel activity in living cells. This article will revie...
متن کاملLaser-Driven Ion Acceleration from Plasma Micro-Channel Targets
Efficient energy boost of the laser-accelerated ions is critical for their applications in biomedical and hadron research. Achiev-able energies continue to rise, with currently highest energies, allowing access to medical therapy energy windows. Here, a new regime of simultaneous acceleration of ~100 MeV protons and multi-100 MeV carbon-ions from plasma micro-channel targets is proposed by usin...
متن کاملIon channel targets and treatment efficacy in neuropathic pain.
UNLABELLED Chronic neuropathic pain due to injury or dysfunction of the nervous system remains a formidable treatment challenge in spite of a growing range of medication choices. We review current clinical research supporting the use of ion channel modulators for neuropathic pain states. New modes of local drug delivery, novel Ca2+ channel targets, and increased choices for drugs with activity ...
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ژورنال
عنوان ژورنال: Channels
سال: 2015
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2015.1081725