Valvular osteoclasts in calcification and aortic valve stenosis severity
نویسندگان
چکیده
منابع مشابه
Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation?
RATIONALE Calcific aortic stenosis (AS) is characterized by calcium deposition in valve leaflets. However, women present lower aortic valve calcification loads than men for the same AS hemodynamic severity. OBJECTIVE We, thus, aimed to assess sex differences in aortic valve fibrocalcific remodeling. METHODS AND RESULTS One hundred and twenty-five patients underwent Doppler echocardiography ...
متن کاملGenetic associations with valvular calcification and aortic stenosis.
BACKGROUND Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. METHODS We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; th...
متن کاملValve Calcification in Aortic Stenosis: Etiology and Diagnostic Imaging Techniques
Aortic stenosis is the most common valvulopathy in the Western world. Its prevalence has increased significantly in recent years due to population aging; hence, up to 8% of westerners above the age of 84 now have severe aortic stenosis (Lindroos et al., 1993). This causes increased morbidity and mortality and therein lies the importance of adequate diagnosis and stratification of the degree of ...
متن کاملMolecular Mechanisms of Inflammation and Calcification in Aortic Valve Stenosis
Aortic valve stenosis is a slowly progressive disorder with a spectrum of disease ranging from aortic sclerosis to severe destroyed valvular architecture leading to critical outflow obstruction. The diseased valve is characterized by inflammation, as an initiating event, pathological remodeling of extracellular matrix and pronounced calcification, which all eventually cause restricted leaflet m...
متن کاملValvular Aortic Stenosis
Standard echocardiographic evaluation of aortic stenosis (AS) severity includes measurement of aortic velocity, mean transaortic pressure gradient, and continuity equation valve area. Although these measures are adequate for decision making in most patients, there is no single value that defines severe stenosis. Aortic stenosis affects not just the valve, but the entire vascular system, includi...
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ژورنال
عنوان ژورنال: International Journal of Cardiology
سال: 2013
ISSN: 0167-5273
DOI: 10.1016/j.ijcard.2013.01.207