Vascular Dysfunction in Hyperglycemia
نویسندگان
چکیده
منابع مشابه
Vascular dysfunction in hyperglycemia: is protein kinase C the culprit?
Diabetes mellitus (DM) is the seventh leading cause of death in the United States with accelerated cardiovascular disease accounting for most ( 75%) of the mortality. Major complications include retinopathy, nephropathy, neuropathy, and vasculopathy. Each has been linked to the severity of hyperglycemia; thus, the mainstay of treatment has been to aggressively control serum glucose levels. This...
متن کاملPotential therapeutic effect of Moroccan propolis in hyperglycemia, dyslipidemia, and hepatorenal dysfunction in diabetic rats
Objective(s): The effect of propolis collected in Morocco on blood glucose, lipid profile, liver enzymes, and kidney function was investigated in control and diabetic rats. Materials and Methods: Antioxidant activity of propolis was evaluated with the use of DPPH, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+), ferric ...
متن کاملFoxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells
OBJECTIVE Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading from hyperglycemia to oxLDL formation and eNOS dysfunction is unknown. RESEA...
متن کاملMicroRNAs in Hyperglycemia Induced Endothelial Cell Dysfunction.
Hyperglycemia is closely associated with prediabetes and Type 2 Diabetes Mellitus. Hyperglycemia increases the risk of vascular complications such as diabetic retinopathy, diabetic nephropathy, peripheral vascular disease and cerebro/cardiovascular diseases. Under hyperglycemic conditions, the endothelial cells become dysfunctional. In this study, we investigated the miRNA expression changes in...
متن کاملVascular Dysfunction in Leukoaraiosis.
BACKGROUND AND PURPOSE The pathogenesis of leukoaraiosis has long been debated. This work addresses a less well-studied mechanism, cerebrovascular reactivity, which could play a leading role in the pathogenesis of this disease. Our aim was to evaluate blood flow dysregulation and its relation to leukoaraiosis. MATERIALS AND METHODS Cerebrovascular reactivity, the change in the blood oxygen le...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.90.1.5