Vascular smooth muscle cell contractile function and mechanotransduction
نویسندگان
چکیده
منابع مشابه
The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function.
Smooth muscle (SM) exhibits a highly organized structural hierarchy that extends over multiple spatial scales to perform a wide range of functions at the cellular, tissue, and organ levels. Early efforts primarily focused on understanding vascular SM (VSM) function through biochemical signaling. However, accumulating evidence suggests that mechanotransduction, the process through which cells co...
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For many years the simple view was held that contractile force in smooth muscle was proportional to cytosolic Ca2+ concentrations ([Ca2+]i). With the discovery that phosphorylation of myosin light chain by Ca2+/calmodulin-dependent myosin light chain kinase initiated contraction, regulation of the contractile elements developed more complex properties. Molecular and biochemical investigations h...
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The Human Genome Project was barely completed in 2003 before a new quest was launched: this time, in a search for short stretches of RNA called microRNA. The belief that these miniature molecules, which had only been discovered a decade earlier, were major regulators of genetic function gained momentum in the intervening years and sparked a worldwide interest in the physiologic and pathologic r...
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Segments of dog common carotid artery were excised, cannulated, and restored to in situ length, They were immersed in a Krebs-Ringer's bath and inflated with 100% O., under nonoscillating pressure. Diameter was continuously monitored with a linear displacement transducer. The vessel segments were relaxed and then treated isometrically with norepinephrine to excite the muscle. These continuously...
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ژورنال
عنوان ژورنال: Vessel Plus
سال: 2018
ISSN: 2574-1209
DOI: 10.20517/2574-1209.2018.51