Vasoactive intestinal peptide (VIP): Binding in different organs in the rat
نویسندگان
چکیده
منابع مشابه
Vasoactive intestinal peptide (VIP).
In 1969, Said and Mutt reported the extraction from secretion, increased flow of alkaline pancreatic normal lung tissue of a peptide which was capable juice and small intestinal juice with increased cyclic of causing gradual but prolonged peripheral AMP content (Makhlouf and Said, 1975), overlap vasodilation. This finding led them to search for markedly with the actions of the other three pepti...
متن کاملVasoactive intestinal peptide (VIP) binding to solubilized material from rat liver plasma membranes.
A non-ionic detergent such as Lubrol-PX extracts in soluble form the VIP-binding structures of rat liver plasma membranes. Detergent-solubilized proteins bind specifically [125I]VIP and the complex tracer-protein is identified by the use of Sepharose 6B columns. The interaction is only possible in the absence of detergent (below 0.001%) and is inhibited by native peptide. A molecular weight of ...
متن کاملCharacterization of functional receptors for vasoactive intestinal peptide (VIP) in rat peritoneal macrophages.
Functional vasoactive intestinal peptide (VIP) receptors have been characterized in rat peritoneal macrophages. The binding depended on time, temperature and pH, and was reversible, saturable and specific. Scatchard analysis of binding data suggested the presence of two classes of binding sites: a class with high affinity (kd = 1.1 +/- 0.1 nM) and low capacity (11.1 +/- 1.5 fmol/10(6) cells), a...
متن کاملModulation by vasoactive intestinal peptide (VIP) of serotonin receptors in membranes from rat hippocampus.
The vasoactive intestinal peptide (VIP) has been located in various structures of the rat brain, but few actions of the peptide have been reported as yet. Because VIP might interact with classical neurotransmitter systems in the central nervous system as it does in the periphery, we investigated whether VIP can modulate serotonin (5-HT1) receptors in membrane preparations obtained from brain ar...
متن کاملStimulatory effect of vasoactive intestinal peptide (VIP) on cyclic AMP production in rat peritoneal macrophages.
Vasoactive intestinal peptide (VIP) stimulated cyclic AMP production in rat peritoneal macrophages. The stimulatory effect of VIP was dependent on time, temperature and cell concentration, and was potentiated by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). At 15 degrees C, the response occurred in the 0.1-1000 nM range of VIP concentrations. Half maximal stimulation of ce...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)93193-1