VEGF/VEGFR-2 mRNA Expression in a Mouse Menstrual-Like Model by Pharmacologic Progesterone Withdrawal
نویسندگان
چکیده
منابع مشابه
A critical period of progesterone withdrawal precedes endometrial breakdown and shedding in mouse menstrual-like model.
STUDY QUESTION Is there a critical period of progesterone (P4) withdrawal in a mouse menstrual-like model, and at what time after P4 withdrawal endometrial breakdown become irreversible? STUDY ANSWER Our results showed that a 12-16 h critical period of P4 withdrawal exists in the mouse menstrual-like model. WHAT IS KNOWN ALREADY P4 withdrawal is the trigger for endometrial breakdown and she...
متن کاملMenstrual-like changes in mice are provoked through the pharmacologic withdrawal of progesterone using mifepristone following induction of decidualization.
BACKGROUND Cyclic shedding of the endometrium is unique to menstruating species, and mouse menstruation models by physiologic progesterone withdrawal have been previously reported. Since progesterone action ablated pharmacologically may provide more insight into the mechanism of action, a mouse menstruation model using mifepristone was established. METHODS Mifepristone was administered follow...
متن کاملActive Role of the Predecidual-Like Zone in Endometrial Shedding in a Mouse Menstrual-Like Model
Cyclic shedding of the endometrium is unique to menstruating species. The status of the decidua in mouse menstrual-like models seems to differ from that of the predecidua in humans before endometrial breakdown. The aim of this study was to determine how this difference in decidual status is related to endometrial breakdown. A mouse menstrual-like model was generated by pharmacological progester...
متن کاملComprehensive Analysis of Leukocytes, Vascularization and Matrix Metalloproteinases in Human Menstrual Xenograft Model
In our previous study, menstrual-like changes in mouse were provoked through the pharmacologic withdrawal of progesterone with mifepristone following induction of decidualization. However, mouse is not a natural menstruation animal, and the menstruation model using external stimuli may not truly reflect the occurrence and development of the human menstrual process. Therefore, we established a m...
متن کاملProgesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium.
In human parturition, progesterone withdrawal and estrogen activation are not mediated by changes in progesterone and estrogen levels. Instead, these events could be facilitated by changes in the responsiveness of the myometrium to progesterone and estrogens via changes in PR and ER expression. We hypothesized that functional progesterone withdrawal occurs by increased expression of the type A ...
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ژورنال
عنوان ژورنال: Journal of Animal and Veterinary Advances
سال: 2012
ISSN: 1680-5593
DOI: 10.3923/javaa.2012.3512.3516