منابع مشابه
Regulation of Francisella Tularensis Virulence
Francisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp. must be able to survive in diverse environmental niches. However, F. tularensis has a surprising dearth of sensory and regulatory factors. Recent...
متن کاملNutritional virulence of Francisella tularensis
One of the most fundamental aspects of infectious diseases is microbial acquisition of nutrients in vivo, which impacts virulence and antibiotic treatment. Therefore, it is not surprising that part of the innate host defense against microbial infection is to limit access of various invading pathogens to sources of host nutrients (Abu Kwaik and Bumann, 2013; Eisenreich et al., 2013). Despite thi...
متن کاملVirulence Differences Among Francisella tularensis Subsp. tularensis Clades in Mice
Francisella tularensis subspecies tularensis (type A) and holarctica (type B) are of clinical importance in causing tularemia. Molecular typing methods have further separated type A strains into three genetically distinct clades, A1a, A1b and A2. Epidemiological analyses of human infections in the United States suggest that A1b infections are associated with a significantly higher mortality rat...
متن کاملIdentification of an essential Francisella tularensis subsp. tularensis virulence factor.
Francisella tularensis, the highly virulent etiologic agent of tularemia, is a low-dose intracellular pathogen that is able to escape from the phagosome and replicate in the cytosol. Although there has been progress in identifying loci involved in the pathogenicity of this organism, analysis of the genome sequence has revealed few obvious virulence factors. We previously reported isolation of a...
متن کاملIron and Virulence in Francisella tularensis
Francisella tularensis, the causative agent of tularemia, is a Gram-negative bacterium that infects a variety of cell types including macrophages, and propagates with great efficiency in the cytoplasm. Iron, essential for key enzymatic and redox reactions, is among the nutrients required to support this pathogenic lifestyle and the bacterium relies on specialized mechanisms to acquire iron with...
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ژورنال
عنوان ژورنال: Journal of Hygiene
سال: 1977
ISSN: 0022-1724
DOI: 10.1017/s0022172400052840