Vitamin E intake and multiple health outcomes: an umbrella review

Background The benefits of vitamin E (VE) for multiple health outcomes have been well evaluated in many recent studies. Objective purpose this umbrella review was to conduct a systematic evaluation the possible associations between VE intake and various outcomes. Methods We systematically searched databases, such as PubMed, Embase, Web Science, identify related meta-analyses observational studies randomized trials. estimated effect size each association by using random or fixed effects models 95% confidence intervals. used standard approaches evaluate quality articles (AMSTAR) classified evidence into different levels (GRADE). Results A total 1,974 were searched, 27 with 28 yielded according our exclusion criteria. inversely associated risk breast cancer, lung esophageal gastric pancreatic kidney bladder cervical neoplasms, cardiovascular disease, Parkinson's depression, age-related cataracts, metabolic syndrome, fracture. Overall, most low very low. Three (stroke, obesity) identified having “moderate” level quality. AMSTAR scores all ranged from 5 10. Conclusion Our study revealed that is beneficially However, future on recommended doses populations are also needed. Systematic registration http://www.crd.york.ac.uk/PROSPERO/ , identifier: CRD42022339571.