Voltage-gated sodium channels as targets for pyrethroid insecticides
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چکیده
منابع مشابه
Voltage gated sodium channels as drug discovery targets.
Voltage-gated sodium (NaV) channels are a family of transmembrane ion channel proteins. They function by forming a gated, water-filled pore to help establish and control cell membrane potential via control of the flow of ions between the intracellular and the extracellular environments. Blockade of NaVs has been successfully accomplished in the clinic to enable control of pathological firing pa...
متن کاملVoltage-gated sodium channels: therapeutic targets for pain.
OBJECTIVE To provide an overview of the role of voltage-gated sodium channels in pathophysiology of acquired and inherited pain states, and of recent developments that validate these channels as therapeutic targets for treating chronic pain. BACKGROUND Neuropathic and inflammatory pain conditions are major medical needs worldwide with only partial or low efficacy treatment options currently a...
متن کاملVoltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملVOLTAGE-GATED ION CHANNELS Voltage-Gated Sodium Channels
Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
متن کاملNav1.7 and other voltage-gated sodium channels as drug targets for pain relief
INTRODUCTION Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects. AREAS COVERED Sodium channel subtypes have been linked to human pain syndromes through genetic studies. Gain of function mutations in Nav1.7, 1.8 and 1.9 can cause pain, whilst loss of function Nav1.7 mutations lea...
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ژورنال
عنوان ژورنال: European Biophysics Journal
سال: 2017
ISSN: 0175-7571,1432-1017
DOI: 10.1007/s00249-016-1195-1