Volume and Infusion Rate Dynamics of Intraparenchymal Central Nervous System Infusion in a Large Animal Model

PRACTICAL PROBLEMS AND THE EFFICACY OF INTRAOSSEOUS INFUSION: SOLVING THE PROBLEMS BY EMPLOYING AN ANIMAL MODEL

In critically ill infants and children, intravascular (IV) access is sometimes very difficult. In such cases intraosseous (IO) infusion should be used as the method of choice. However, in practice, different problems are experienced with this procedure. To overcome the practical problems and to confirm the efficacy of IO infusion in reversing hypovolemic shock, an animal model was used by ...

Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy.

Arylsulfatase A (ASA) catalyzes the desulfation of sulfatide, a major lipid component of myelin. Inherited functional deficiencies of ASA cause the lysosomal storage disease (LSD) metachromatic leukodystrophy (MLD), which is characterized by intralysosomal accumulation of sulfatide, progressive neurological symptoms and early death. Enzyme replacement therapy (ERT) using intravenous injection o...

Encephalomyelitis and Suppresses Experimental Autoimmune Immunoprivilege of Central Nervous System Intrathecal Fas Ligand Infusion Strengthens

Teaching Critical Thinking through a Dialogic Approach: The infusion model

Abstract Recent interest in teaching thinking has lead different researchers to examine different approaches in education to find effective methods and approaches for teaching thinking. Through a qualitative case analysis, this study attempted to identify the effects of the infusion model of teaching thinking implemented through a dialogic approach on a PhD candidate’s critical thinking skills....

HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS

In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...