Warfarin in Complex Older Patients: Have we Reached a Tipping Point?

Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’

Healthy men produce an enormous number of sperms, far more than necessary for conception. However, several studies suggest that semen samples where the concentration of sperms is below 40 mill/mL may be associated with longer time to pregnancy or even subfertility, and specimens where the concentration of sperms is below 15 mill/mL may carry a high risk of infertility. Historic data from the 19...

The 30-year war on AIDS: have we reached the tipping point?

I is truly an honor to receive the Thomas Parran Award, and I wish to express my deep thanks and gratitude to the American Sexually Transmitted Diseases Association and the Thomas Parran Award Committee for selecting me to receive this prestigious award. I would like to recognize the support of my colleagues who provided mentorship and guidance to me throughout my career. My lifelong interest i...

The future of employment-based health benefits: have employers reached a tipping point?

Opioids in chronic noncancer pain: have we reached a boiling point yet?

As we say goodbye to 2013, 2014 brings in the global epidemic of opioid use, inappropriate use, and abuse with related fatalities, which along with the global epidemic of chronic pain with its related disability continue to be major issues for the public, officials, and physician community (1-11). After much controversy with pendulums swinging in different directions over the last 3 decades, it...

The Thinning of Arctic Sea Ice, 1988–2003: Have We Passed a Tipping Point?

Recent observations of summer Arctic sea ice over the satellite era show that record or near-record lows for the ice extent occurred in the years 2002–05. To determine the physical processes contributing to these changes in the Arctic pack ice, model results from a regional coupled ice–ocean model have been analyzed. Since 1988 the thickness of the simulated basinwide ice thinned by 1.31 m or 4...