WD40 Repeats Arrange Histone Tails for Spreading of Silencing
نویسندگان
چکیده
منابع مشابه
WD40 repeats arrange histone tails for spreading of silencing.
Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosophila chromosome from the UBX (Hox gene) promoter to the PBX upstream enhancer region, implying EED initiates prop...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2009
ISSN: 1674-2788
DOI: 10.1093/jmcb/mjp046