What can hide an enlarged lymph node of a patient with prostatic adenocarcinoma?

Introduction. Adenocarcinoma is the most common prostatic malignancy where clinical management, Gleason score and recent updates in prostate cancer staging play critical role. Mantle cell lymphoma originates from malignant transformation of B lymphocyte outer edge lymph node follicle, with pathognomonic overexpression cyclin D1. We present a rare case two neoplasms occurred same individual person. Case report. In 68-year-old patient planned for radical prostatectomy during hospital preoperative examinations using multislice computed tomography tumor mass confined to but also excessive enlargement were revealed. Tissue specimens analyzed after hematoxylin eosin staining, as well immunohistochemical biomarker panel. Having performed thorough histological examination, diagnosis adenocarcinoma, 3+4=7, ISUP GG2, was given. Microscopic analysis involvement showed unexpected, diffuse proliferation small lymphoid cells, irregular nuclei, wide mantle zone hyalinized blood vessels. After staining specific markers, another set, it non Hodgkin lymphoma. Conclusion. A adenocarcinoma can extremely rarely be coexistence undiagnosed lymphoproliferative disease, such our case.