What makes microbial co-cultures a unique approach to discovering natural products?

Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products

Historically, nature has provided the source for the majority of the drugs in use today. This owes in large part to their structural complexity and clinical specificity. However, only a small percentage of known microbial secondary metabolites have been tested as natural-product drugs. Natural-product programs need to become more efficient, starting with the collection of environmental samples,...

What makes cementum a unique structure?

Cementum was first described by Denton GB in 1835 as a calcified, avascular mesenchymal tissue that covers the entire root surface. It approximately comprises of 50% of hydroxyappetite and 50% of organic matrix which consist of non collagenous and collagenous proteins. Protein extract of mature cementum promotes cell attachment, migration and stimulates protein synthesis of gingival fibroblast ...

What Makes Choice Natural?

The idea to use choice functions in the semantic analysis of indefinites has recently gained increasing attention among linguists and logicians. A central linguistic motivation for the revived interest in this logical perspective, which can be traced back to the epsilon calculus of Hilbert & Bernays (1939), is the observation by Reinhart (1992, 1997) that choice functions can account for the pr...

marine microbial natural products

Centromeric chromatin: what makes it unique?

Centromeres represent the final frontier of eukaryotic genomes. Although they are defining features of chromosomes--the points at which spindle microtubules attach--the fundamental features that distinguish them from other parts of the chromosome remain mysterious. The function of centromeres is conserved throughout eukaryotic biology, but their DNA sequences are not. Rather, accumulating evide...