Wilms tumor 1 protein is not expressed in oral lymphangiomas

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Wilms Tumor 1 protein is not expressed in oral lymphangiomas.

Lymphangiomas are benign hamartomatous lesions of lymphatic vessels. Wilms Tumor 1 (WT1) is a transcription factor that is activated in some human neoplasias. WT1 protein expression is observed in endothelial cells during angiogenesis and is a useful marker to distinguish between vascular proliferations and vascular malformations. The purpose of the present study is to report a case series of o...

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Immunohistochemical expression of Wilms' tumor 1 protein in nephroblastoma.

BACKGROUND Approximately 10% of nephroblastomas (Wilms' tumors) carry mutations in the Wilms' tumor 1 (WT1) gene. Recently, a WT1 antibody raised against N-terminal 1-181 amino acids of human WT1 became commercially available for immunohistochemical use on paraffin-embedded tissue. The aim of this study was to investigate the diagnostic and prognostic value of WT1 N-terminal antibody in nephrob...

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Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.

We analyzed Wilms' tumor suppressor 1 (WT1) expression and its regulation by promoter methylation in a panel of normal breast epithelial samples and primary carcinomas. Contrary to previous reports, WT1 protein was strongly expressed in primary carcinomas (27 of 31 tumors) but not in normal breast epithelium (1 of 20 samples). Additionally, the WT1 promoter was methylated in 6 of 19 (32%) prima...

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The E2F3-Oncomir-1 axis is activated in Wilms' tumor.

Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expression profiling of both mRNA and miRNAs in Wilms' tumor (WT) samples to provide the first evidence that the E2F3-Oncomir-1 axis, previously identified in cell culture, is deregul...

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MiR-21 Expression in Wilms’ Tumor

Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children...

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ژورنال

عنوان ژورنال: Brazilian Dental Journal

سال: 2012

ISSN: 0103-6440

DOI: 10.1590/s0103-64402012000600014