X-ray Structure Analysis of (dl)-DeN-Corynoline, Derived from Hexahydorobenzo[c]phenanthridine Type Alkaloid Corynoline
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چکیده
منابع مشابه
In Vitro and In Vivo Characterization of Reactive Intermediates of Corynoline.
Corynoline is a 1,3-benzodioxole-containing isoquinoline alkaloid isolated from Corydalis bugeana Turcz., a traditional herbal medicine. Corynoline has reportedly demonstrated multiple pharmacologic properties. Previous studies have also shown that corynoline induced cytotoxicity and inhibited cytochrome P450 (CYP) enzymes, but the mechanisms of the adverse effects remain unknown. The major obj...
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Corydalis bungeana Turcz. is an anti-inflammatory medicinal herb used widely in traditional Chinese medicine for upper respiratory tract infections. It is demonstrated that corynoline is its active anti-inflammatory component. The nuclear factor-erythroid-2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway and the mitogen-activated protein kinase (MAPK) pathway play important r...
متن کاملIdentification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions.
Corynoline, an isoquinoline alkaloid isolated from the genus Corydalis, has been demonstrated to show multiple pharmacological effects including inhibition of acetylcholinesterase, inhibition of cell adhesion, fungitoxic and cytotoxic activity. The present study focused on its metabolism and metabolism-based herb-drug interactions. After corynoline was incubated with human liver microsomes (HLM...
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An X-ray structure analysis of a crystal of mutant Asp229----Ala of cyclodextrin glycosyltransferase from Bacillus circulans (Ec 2.4.1.19) that had been shortly exposed to beta-cyclodextrin showed density corresponding to a maltose bound at the catalytic center. The crystal structure was refined to an R-factor of 18.7% at 2.5-A resolution. The catalytic center is defined by homology with the st...
متن کاملX-ray peak broadening analysis in LaMnO3+δ nano-particles with rhombohedral crystal structure
In this work, structural and magnetic properties of LaMnO3+δ compound prepared by citrate precursor method and annealed in presence of oxygen are investigated. The structural characterization of LaMnO3+δ by X-ray powder diffraction and using X’pert package and Fullprof program is evidence for a rhombohedral structure (R-3c space group) confirmed by FTIR measurement. The magnetic measurements sh...
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ژورنال
عنوان ژورنال: X-ray Structure Analysis Online
سال: 2009
ISSN: 1883-3578
DOI: 10.2116/xraystruct.25.27