Xenopus fibrillin regulates directed convergence and extension
نویسندگان
چکیده
منابع مشابه
The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus.
We cloned Xenopus Strabismus (Xstbm), a homologue of the Drosophila planar cell or tissue polarity gene. Xstbm encodes four transmembrane domains in its N-terminal half and a PDZ-binding motif in its C-terminal region, a structure similar to Drosophila and mouse homologues. Xstbm is expressed strongly in the deep cells of the anterior neural plate and at lower levels in the posterior notochorda...
متن کاملFibrillin-1 regulates the bioavailability of TGFβ1
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a major contributor to the pathology of Marfan syndrome (MFS) and related diseases. In the presence of cell layer extracellular matrix, a fibrillin-1 s...
متن کاملThe patterning and functioning of protrusive activity during convergence and extension of the Xenopus organiser.
We discuss the cellular basis and tissue interactions regulating convergence and extension of the vertebrate body axis in early embryogenesis of Xenopus. Convergence and extension occur in the dorsal mesoderm (prospective notochord and somite) and in the posterior nervous system (prospective hindbrain and spinal cord) by sequential cell intercalations. Several layers of cells intercalate to for...
متن کاملIntegrin α5β1 and Fibronectin Regulate Polarized Cell Protrusions Required for Xenopus Convergence and Extension
Background: Integrin recognition of fibronectin is required for normal gastrulation including the mediolateral cell intercalation behaviors that drive convergent extension and the elongation of the frog dorsal axis; however, the cellular and molecular mechanisms involved are unclear. Results: We report that depletion of fibronectin with antisense morpholinos blocks both convergent extension and...
متن کاملXenopus ADAM13 and ADAM19 are Important for Proper Convergence and Extension of the Notochord
...................................................................................................................... vi LIST OF TABLES ............................................................................................................ xii LIST OF FIGURES ......................................................................................................... xiii CHAPTER
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2007
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.09.005