YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins
نویسندگان
چکیده
منابع مشابه
YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.
Mutant p53 proteins are present in more than half of human cancers. Yes-associated protein (YAP) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and cancer. Here, we report that these two determinants of human malignancy share common transcriptional signatures. YAP physically interacts with mutant p53 proteins in breast cancer cells and potentiates their pro-pro...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2015
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201540488