analgesic and anti-inflammatory activity of teucrium chamaedrys leaves aqueous extract in male rats

نویسندگان

ali pourmotabbed department of physiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran

amir farshchi department of physiology, school of medicine, kermanshah university of medical sciences, kermanshah, iran

department of pharmacoeconomy and pharmaceutical management, school of pharmacy, tehran university of medical sciences, tehran, iran

student scientific research center, tehran university of medical sciences, tehran, iran

چکیده

objective(s) current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of teucrium chamaedrys in mice and rats. materials and methods for evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. results the extract of t. chamaedrys (50-200 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant (p< 0.01) inhibition of the second phase response in the formalin pain model, while only the high dose (200 mg/kg) of the extract showed an analgesic effect in the first phase. the extract also inhibited acetic acid-induced abdominal writhes in a dose-dependent manner. the tail flick latency was dose dependently enhanced by the extract but this was significantly (p< 0.05) lower than that produced by morphine (10 mg/kg). the extract (25-250 mg/kg) administered 1 hr before carrageenan-induced paw swelling produced a dose dependent inhibition of the oedema. no effect was observed with the dextran-induced oedema model. results of the phytochemical screening show the presence of alkaloids, flavonoids and triterpenoids in the extract. conclusion the data obtained also suggest that the anti-inflammatory and analgesic effects of the extract may be mediated via both peripheral and central mechanisms. the role of alkaloids, flavonoids and triterpenoids will evaluate in future studies.

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Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۳، شماره ۳، صفحات ۱۱۹-۱۲۵

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