effect of tetanus‑diphtheria vaccine on immune response to hepatitis b vaccine in low‑responder individuals
background: conventional hepatitis b virus (hbv) vaccination fails to achieve efficient protection in about 5–10% of the world population. hence, different strategies have been adopted to ameliorate hbv antibody titers. this study aimed to evaluate the concurrent application of tetanus‑diphtheria (td) and hbv vaccination on hepatitis b surface (hbs) antibody titer in low‑responder healthy individuals. methods: this was a randomized clinical trial, which was implemented among 140 of medical staff working as health‑care workers assumed as low‑responders. the subjects were randomly allocated to either control or interventional groups. the control and interventional groups received hbv recombinant vaccine while the latter group was also vaccinated through td. enzyme‑linked immunosorbent assay was applied to measure hbs antibody (hbsab) titers just before and 6 months after the last vaccination. all data were entered into spss software. independent t‑test, paired t‑test, and chi‑square or fisher’s exact test were applied for data comparison. results: antibody titers of the subjects in the intervention and control groups soared from 49.08 ± 20.08 iu/l to 917.78 ± 204.80 iu/l and from 46.95 ± 18.55 to 586.81 ± 351.77 iu/l, respectively (both p < 0.001); nevertheless, by comparison with control group, variation of antibody titer in the interventional group was significantly higher (p <0.001). conclusions: concurrent application of td and hbv vaccine could effectively enhance protective levels of hbsab titers in low‑responder individuals.
Effect of Tetanus-diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-responder Individuals
BACKGROUND Conventional hepatitis B virus (HBV) vaccination fails to achieve efficient protection in about 5-10% of the world population. Hence, different strategies have been adopted to ameliorate HBV antibody titers. This study aimed to evaluate the concurrent application of tetanus-diphtheria (Td) and HBV vaccination on hepatitis B surface (HBs) antibody titer in low-responder healthy indivi...متن کامل
effect of tetanus-diphtheria (td) vaccine on immune response to hepatitis b vaccine in healthy individuals with insufficient immune response
background: hepatitis b virus (hbv) fails to produce appropriate immune responses in some healthy individuals; thus, different strategies have been adopted to promote immune responses. the current study aimed at evaluating the efficacy of hbv vaccine coadministered with tetanus-diphtheria (td) vaccine compared with hbv vaccine in healthy individuals through measuring hepatitis b surface antibod...متن کامل
Distribution of Circulating Immune Cells in Responder and Non-Responder Individuals to Hepatitis B Vaccine
Unresponsiveness to hepatitis B surface antigen (HBsAg) has been shown to be associated with dysfunction of the presenting cells (APC) and defect in the specific B-lymphocyte and/or T-lymphocyte repertoires. Direct determination of the frequency of specific T-lymphocytes together with complementary analysis of the naive circulating immune cells could provide valuable information about the cel...متن کامل
The factors influencing the immune response to hepatitis B vaccine and persistence of the protection.
Hepatitis B virus (HBV) infection and its sequelae which include cirrhosis and hepatocellular carcinoma is a major public health problem throught the world.The WHO strategy for effective control of HBV infection is vaccination with the surface antigen of virus(HBsAg).The results obtained from a large number of studies demonstrated that the vaccine induces a protective antibody resonse (anti-HB...متن کامل
Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients
Background: Poor response to various vaccines especially hepatitis B is common. The purpose of this study was to evaluate the effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.Methods: In this randomized clinical trial study, 62 insulin dependent diabetic patients were divided into case and control groups (e...متن کامل
background: hepatitis b infection is a major public health problem worldwide. dental students who are frequently in contact with body fluids like blood and saliva are still at high risk for hbv exposure. the aim of this study was to evaluate the effectiveness of hbv vaccine and personal factors associated with serologic evidence of the immune response. methods: a descriptive-cross sectional stu...متن کامل