serologic evaluation of celiac disease in patients with beta thalassemia major and control

iraj shahramian fellow of pediatric gastroentrology ,assistant professor of pediatric, department of pediatric, zabol university of medical sciences, zabol iran, seyed mohsen dehghani professor of pediatric gastroentrology, department of pediatric gastroentrology, shiraz university of medical sciences, shiraz iran, mahmood haghighat professor of pediatric gastroentrology , department of pediatric gastroentrology, shiraz university of medical sciences, shiraz iran, noormohamad noori professor of pediatric cardiology , children and adolescents health research center ,zahedan medical university ,iran, alireza teymoori assistant professor of demography , children and adolescents health research center ,zahedan medical university ,iran, elham sharafi resident of ophtalmology ,zahedan medical university ,zahedan ,iran

چکیده

abstract introduction : celiac disease (cd) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals. this study reports evaluated prevalence of cd in patients with beta-thalassemia major. materials and methods: in this case-control study in a period of 3 years which was performed on 620 children in two groups of beta-thalassemia major patients (n=200) and control (n=420), serum tissue transglutamianse (ttg) iga levels were measured. the two groups were compared together in terms of ttg iga levels, and p<0.05 was considered significant. results : the means of serum ttg iga levels in patients with beta-thalassemia major and control groups were 28.81±68.44 and 6.94±6.68 u/ml, respectively, there was a significant difference in favor of the case group (p=0.000). body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). belonging to each group will change the probability of having less than 20 in ttg iga (odds=0.285) and it means that belonging to the control group has a protective role. there is only a significant association in the case of all population (r=0.102, p=0.011). body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). discussion : probability of cd should be considered since the prevalence of cd is high in patients with and beta-thalassemia major. patients with thalassemia major are recommended to be screened for cd. keywords : celiac disease, beta-thalassemia major, growth disorder, disease risk, hla