Anthrax Lethal Factor Activates K Channels To Induce IL-1b Secretion in Macrophages
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منابع مشابه
Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages.
Anthrax lethal toxin (LeTx) is a virulence factor of Bacilillus anthracis that is a bivalent toxin, containing lethal factor (LF) and protective Ag proteins, which causes cytotoxicity and altered macrophage function. LeTx exposure results in early K(+) efflux from macrophages associated with caspase-1 activation and increased IL-1β release. The mechanism of this toxin-induced K(+) efflux is unk...
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تاریخ انتشار 2011