Insights into schizophrenia using positron emission tomography: building the evidence and refining the focus.

نویسندگان

  • Nora S Vyas
  • Neva H Patel
  • Kuldip S Nijran
  • Adil Al-Nahhas
  • Basant K Puri
چکیده

Schizophrenia involves dysregulation in dopaminergic transmission. Studies show heightened presynaptic striatal dopaminergic function and elevated striatal D(2)/D(3) receptor density in the brain. Cognitive impairments result from hypostimulation of D(1) receptors and are associated with dysfunction in the prefrontal cortex. Here we discuss relevant positron emissions tomography (PET) studies and provide future directions.

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عنوان ژورنال:
  • The British journal of psychiatry : the journal of mental science

دوره 197 1  شماره 

صفحات  -

تاریخ انتشار 2010