Simulating Concerted Evolution

Teshima and Innan, in [1], describes simulation results for duplicated genes under concerted evolution. Their simulation method evolves a pair of initially identical genes; mutations can accumulate in the two genes—under an infinite sites mutation model—causing divergence between the genes, and gene conversions can occur between the two genes, reducing the divergence again. Their method, however, does not take into account the diversity on the individual gene level found in the population where the genes evolve, and how gene conversion between homologue genes (intra gene conversion) interfere with the gene conversions between the two paralogue genes (inter gene conversion).