[Effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine].

OBJECTIVE To study the effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine. METHODS Sorbaria sorbifolia was perfused into stomach of rats with DEN-induced precancerosis, then the biochemical indexes were investigated. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH) were investigated by colorimetric method. RESULTS Sorbaria sorbifolia extract increased SOD, GSH-PX and decreased MDA, GSH levels in serum and liver homogenate. CONCLUSION Sorbaria Sorbifolia extract significantly increased anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.