Order restricted inference for comparing the cumulative incidence of a competing risk over several populations
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چکیده
There is a substantial literature on testing for the equality of the cumulative incidence functions associated with one specific cause in a competing risks setting across several populations against specific or all alternatives. In this paper we propose an asymptotically distribution-free test when the alternative is that the incidence functions are linearly ordered, but not equal. The motivation stems from the fact that in many examples such a linear ordering seems reasonable intuitively and is borne out generally from empirical observations. These tests are more powerful when the ordering is justified. We also provide estimators of the incidence functions under this ordering constraint, derive their asymptotic properties for statistical inference purposes, and show improvements over the unrestricted estimators when the order restriction holds.
منابع مشابه
Non-parametric inference for cumulative incidence functions in competing risks studies.
In the competing risks problem, a useful quantity is the cumulative incidence function, which is the probability of occurrence by time t for a particular type of failure in the presence of other risks. The estimator of this function as given by Kalbfleisch and Prentice is consistent, and, properly normalized, converges weakly to a zero-mean Gaussian process with a covariance function for which ...
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تاریخ انتشار 2008