Giant Retroperitoneal Mucinous Tumor Supportively Diagnosed as a Dedifferentiated Liposarcoma by Fluorescence In Situ Hybridization of MDM2 Gene
نویسندگان
چکیده
Surgical resection was performed on a 47-year-old woman for a retroperitoneal mass that weighed 8.5 kg. Histological examination revealed a myxoid sarcomatous tumor. Because diagnosis could not be determined by immunohistochemistry, attention was focused on MDM2 (murine double minute) gene amplification by fluorescence in situ hybridization (FISH) analysis. The tumor was finally determined to be a dedifferentiated liposarcoma. We experienced a case of a giant retroperitoneal dedifferentiated liposarcoma. FISH analysis was useful for the diagnosis and determination of the therapeutic strategy.
منابع مشابه
Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh.
Non-retroperitoneal dedifferentiated liposarcoma (DDLS) is relatively uncommon and its characterization at the molecular genetic level has been limited. We describe the cyto-genetic and molecular cytogenetic findings of giant DDLS arising in the right thigh of an 83-year-old woman. Magnetic resonance imaging revealed a mass composed of two components with heterogeneous signal intensities, sugge...
متن کاملRare Aggressive Behavior of MDM2-Amplified Retroperitoneal Dedifferentiated Liposarcoma, with Brain, Lung and Subcutaneous Metastases
Dedifferentiated liposarcoma (DDL) is a histologically pleomorphic sarcoma, traditionally defined as well-differentiated liposarcoma with abrupt transition to high grade, non-lipogenic sarcoma. It can occur as part of recurrent well-differentiated liposarcoma, or may arise de novo. DDL most frequently occurs within the retroperitoneum, and while it is prone to local recurrence, it usually has a...
متن کاملDifferentiating and Categorizing of Liposarcoma and Synovial Sarcoma Neoplasms by Fluorescence in Situ Hybridization
Background & Objective: Soft tissue sarcomas (STS) constitute an uncommon and heterogeneous group of tumors of mesenchymal origin and various cytogenetic abnormalities ranging from distinct genomic rearrangements, such as chromosomal translocations and amplifications, to more intricate rearrangements involving multiple chromosomes. Fluorescence in situ...
متن کاملPrimary Retroperitoneal Myxoid Liposarcomas
Myxoid liposarcomas (MLSs) are genetically defined by the presence of DDIT3 gene fusions and most commonly arise in the extremities of young adults. Whether MLSs develop primarily in the retroperitoneum is controversial, and a recent retrospective study found no molecularly confirmed examples. Because MLSs tend to metastasize to deep soft tissues, purported examples of primary retroperitoneal l...
متن کاملPrimary orbital dedifferentiated liposarcoma with leiomyosarcomatous and low-grade osteosarcomatous differentiation
Liposarcoma originating in the orbit is extremely rare. Herein, we report a dedifferentiated lipo sarcoma arising from the orbit of a Chinese woman. This patient underwent tumor resection at the age of 56 years and recurred 50 months after the initial resection. Histologically, the initial lesion exhibited features of well-differentiated liposarcoma with focal areas of well-differentiated ossif...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011