Immunosuppression by a mouse tumor resembles antigenic competition.
نویسندگان
چکیده
The intraperitoneal injection of gamma-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of manner similar to the suppression caused by the injection of horse erythrocytes and termed antigenic competition. In both cases, the greatest suppression occurred when the sheep erythrocytes were injected at the same site (intraperitoneal) as the tumor or antigen several days after the tumor or antigen and in a dose of 10(8) erythrocytes or less.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 76 6 شماره
صفحات -
تاریخ انتشار 1979