Altered g-secretase activity in mild cognitive impairment and Alzheimer’s disease
نویسندگان
چکیده
(1) Immuno-Biological Laboratories Co., Fujioka, Japan (2) Faculty of Life and Medical Sciences, Departmen Doshisha University, Kyoto, Japan (3) New Energy and Industrial Technology Develo (NEDO), Kanagawa, Japan (4) Department of Neurology, Institute of Brain Scienc Graduate School of Medicine, Hirosaki, Japan (5) Division of Brain Sciences, Department of Geriatr Institute of Development, Aging and Cancer, Tohok Japan (6) Department of Neurology, Brain Research Institut Niigata, Japan (7) Department of Medical Informatics, Niigata Un Dental Hospital, Niigata, Japan (8) Department of Neuropathology, Tokyo Metropolit ontology, Tokyo, Japan
منابع مشابه
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease
We investigated why the cerebrospinal fluid (CSF) concentrations of Aβ42 are lower in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Because Aβ38/42 and Aβ40/43 are distinct product/precursor pairs, these four species in the CSF together should faithfully reflect the status of brain γ-secretase activity, and were quantified by specific enzyme-linked immunosorbent assays ...
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تاریخ انتشار 2012