Cyclophilin D and acetylation: a new link in cardiac signaling.

نویسندگان

  • Maggie P Y Lam
  • Edward Lau
  • David A Liem
  • Peipei Ping
چکیده

CIRCULATION RESEARCH (ISSN 0009-7330) is published semimonthly except one issue per month in November and December and three issues per month in March and August by Lippincott Williams & Wilkins, at 16522 Hunters Green Pkwy, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. Individuals may subscribe for their personal use at the following annual rates: Domestic: $339 for members and $638 for nonmembers. International: $399 for members of an American Heart Association scientific council and $768 for nonmembers. Contact Lippincott Williams & Wilkins for single copy rates and subscription rates for medical professionals in training and for libraries, reading rooms, and other multiple-use institutions. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to CIRCULATION RESEARCH, American Heart Association, Lippincott Williams & Wilkins, 16522 Hunters Green Pkwy, Hagerstown, MD 21740. Online supplementary information Online movie files Available at http://circres.ahajournals.org Featured Article

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Evaluation of Porin Interaction with Adenine Nucleotide Translocase and Cyclophilin-D Proteins after Brain Ischemia and Reperfusion

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Retraction: Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3.

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Cyclophilin D modulates mitochondrial acetylome.

RATIONALE Mice lacking cyclophilin D (CypD(-/-)), a mitochondrial chaperone protein, have altered cardiac metabolism. As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic changes in CypD(-/-) hearts. OBJECTIVE Our aim was to test the hypothesis that loss of CypD alters the cardiac mitochondrial acetylome. ...

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High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

Aim: Sirtuins are NAD+-dependent deacetylases that regulate cell metabolism through protein acetylation/deacetylation, and SIRT3 is the major deacetylase among mitochondrial isoforms. Here, we elucidated the possible role of acetylation of cyclophilin D, a key regulator of the mitochondrial permeability transition pore (mPTP), in mitochondria-mediated cardiac dysfunction induced by ischemia-rep...

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Acetylation of alcohol, phenols, thiols and amine promoted by succinimidinium hydrogensulfate ([H-Suc]HSO4) in the absence of solvent

Succinimidinium hydrogensulfate ([H-Suc]HSO4), as a new and stable derivative of succinimide, is easily prepared by the reaction of succinimide with neat sulfuric acid. This ionic liquid can be used as an efficient catalyst for the acetylation of alcohols, phenols, thiols and amines at room temperature under mild and solvent free conditions. All the products are separated and identified using d...

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عنوان ژورنال:
  • Circulation research

دوره 113 12  شماره 

صفحات  -

تاریخ انتشار 2013