Sim, Wai-lum Winnie Effects of Hypervitaminosis a on the Erythrocyte Membrane
نویسنده
چکیده
Vitamin A and other retinoids are known to have an effect on biological membranes. We measured the effects of retinol, retinoic acid and retinyl palmitate on in vitro osmotic fragility, spontaneous hemolysis and membrane microviscosity of human red blood cells (RBC)., Incorporation of retinol into the erythrocyte membrane was also studied. The effect of large doses of retinol on adenosine dinucleatide phosphate (ADP) and collagen-induced platelet aggregation was also measured. The results demonstrate that all three retinoids induce alterations in RBC manifested by increased osmotic fragility, spontaneous hemolysis and membrane microviscosity. Retinol incorporation into the RBC membrane was dose-dependent and saturable. The second phase of ADP induced platelet aggregation was markedly depressed by retinol while having no effect on collagen induced platelet aggregation. Retinoid administration to rats induced similar in vivo RBC alterations as was seen with retinoid treatment in vitro.
منابع مشابه
Effect of hypervitaminosis A on hemolysis and lipid peroxidation in the rat.
Erythrocytes from rats fed large doses of Vitamin A alone, or large doses of vitamin A and vitamin E or diphenyl-p-phenylene diamine (DPPD) were studied for H2O2-induced hemolysis. The vitamin A-dosed rats were more susceptible than normal rats to H2O2-induced hemolysis. Hemolysis was not accompanied by lipid peroxidation. Nevertheless, the antioxidants vitamin E and DPPD inhibited hemolysis in...
متن کاملImproving Hydrophilicity of Polyethersulfone Membrane Using Silver Nanoparticles for Humic Substances Removal
Silver-impregnated membrane was facilely prepared by ex situ silver nanoparticles (NPs) blending method using polyethersulfone (PES) as the base polymer. A total of three membranes [F1(S0), F2(S0.5) and F3(S2.0)] were fabricated at different weight percentages of polymer and silver (Ag) loadings to compare their effects on membrane morphological and performance properties. All membrane types we...
متن کاملHYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS
In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...
متن کاملThe Assessment of Erythrocyte Reduced Glutathione Concentration in the Neonates suffered from G6PD Deficiency
Abstract Background and Objective: Glutathione as a master antioxidant plays a key role in eliminating free radicals from your body and in preserving cell membrane integrity esp. blood cells. We aimed to assess the Erythrocyte Glutathione level of favism and non-favism neonates. Material and Methods: This study was conducted in Ekbatan hospitals of Hamadan (2009) on 15 favism patients and 60...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012