RAPID COMMUNICATION Thrombomodulin Expression by Human Blood Monocytes and by Human Synovial Tissue Lining Macrophages
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چکیده
Thrombomodulin is an essential cofactor for the activation of the anticoagulant protein C by thrombin. We have identified the expression of thrombomodulin messenger RNA (mRNA) and protein in peripheral blood monocytes. While untreated monocytes expressed thrombomodulin mRNA by Northern blot analysis, lipopolysaccharide-treated cells had decreased mRNA expression. Thrombomodulin antigen was shown in the cytoplasm and on the surface of monocytes by immunohistochemical staining, and thrombomodulin activity was
منابع مشابه
Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages.
Thrombomodulin is an essential cofactor for the activation of the anticoagulant protein C by thrombin. We have identified the expression of thrombomodulin messenger RNA (mRNA) and protein in peripheral blood monocytes. While untreated monocytes expressed thrombomodulin mRNA by Northern blot analysis, lipopolysaccharide-treated cells had decreased mRNA expression. Thrombomodulin antigen was show...
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1. Weiler H, Isermann BH. Thrombomodulin. J Thromb Haemost 2003; 1: 1515–24. 2. McCachren SS, Diggs J, Weinberg JB et al. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood 1991; 78: 3128–32. 3. Satta N, Freyssinet JM, Toti F. The significance of human monocyte thrombomodulin during membrane vesiculation and after stimulation by lipopolysac...
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تاریخ انتشار 2003