Peri Interactions : An X - ray Crystallographic Study of the Structure of 1 , 8 - Bis ( dimethylamino ) naphthalene

The native anomalous phasing method will have greatest application to cases where poor occupancy or multiple substitution occurs, making direct interpretation of isomorphous difference Pattersons difficult. Alternatively, this method may be useful for locating relative origins for the binding sites from several derivatives in unfavorable space groups, such as P1. The major reasons for the success of the method are that full occupancy of the native anomalous scatterer always occurs, the number and types of binding sites are chemically defined, and the X-ray data are inherently more accurate, since no scaling is needed for anomalous pairs and lack of isomorphism never occurs.