Effects of rhBMP-2 on Angiogenesis During Induction of OSCC in the Syrian Hamster Cheek Pouch
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چکیده
Bone defects in the maxillofacial region vary from a small (few millimeters) periodontal defects to the large segmental defects resulting from trauma or surgical excision of malignancy. Such defects typically have complex three-dimensional structural needs, which are difficult to be restored by biomaterials alone without any osteoinduction (Hanasono, 2014; Sadigh et al., 2016). The use of autogenous bone grafts has long been considered the golden standard of comparison for new bone graft materials (Cole et al., 1995). It has the advantages of being progressively incorporated into the bone tissue (osseointegrate), resisting infection, and being potentially capable of growth (osteogenesis) (Liao et al., 2016). However, in the maxillofacial region, large defects that require bone reconstruction sometimes arise from resection of advanced malignancies. These defects requires a vast quantity of bone graft which is not easily afforded by autografts. In addition, autogenous bone graft transfer has many limitations, including donor site morbidity, difficulty restoring the complex 3-dimensional structure of the defect, significantly extending the surgical
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تاریخ انتشار 2016