Three-Dimensional Reconstruction of the Florid Plaque in variant Creutzfeldt-Jakob Diseases

The paper presents the possibility of 3-D reconstruction of the florid plaques obtained in Transmission ElectronMicroscopy. The TEM images registration process is quite different from Nuclear Magnetic Resonance and Computed Tomography on account to increasing amount of the image size and resolution together. The normalisation of image brightness and contrast, produced by differences in slices thickness and differences in time of photograph developing, have also been proposed and discussed. Finally the florid plaque segmentation and reconstruction based on the kmeans clustering algorithm will be demonstrated.