GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins.
نویسندگان
چکیده
PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses such as poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although HRV 3A was previously shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.
منابع مشابه
The 3 A protein from multiple picornaviruses utilizes the Golgi Adaptor Protein ACBD 3 1 to Recruit PI 4
11 12 The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIβ) has been shown to 13 be required for the replication of multiple picornaviruses, however it is unclear whether a 14 physical association between PI4KIIIβ and the viral replication machinery exists and if it 15 does, whether association is necessary. We examined the ability of the 3A protein from 16 18 different picorn...
متن کاملThe 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ.
The activity of phosphatidylinositol 4-kinase class III beta (PI4KIIIβ) has been shown to be required for the replication of multiple picornaviruses; however, it is unclear whether a physical association between PI4KIIIβ and the viral replication machinery exists and, if it does, whether association is necessary. We examined the ability of the 3A protein from 18 different picornaviruses to form...
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عنوان ژورنال:
- Journal of virology
دوره 89 3 شماره
صفحات -
تاریخ انتشار 2015