Determinants of Spike Timing-Dependent Synaptic Plasticity
نویسنده
چکیده
Recent studies show that the precise timing of presynaptic inputs and postsynaptic action potentials influences the strength and sign of synaptic plasticity. In this issue of Neuron, Sjöström and colleagues (2001) determine how this so-called spike timing-dependent plasticity depends on the frequency and strength of the presynaptic inputs.
منابع مشابه
Spike timing dependent plasticity: mechanisms, significance, and controversies
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
متن کاملSpike timing dependent plasticity: mechanisms, significance, and controversies
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
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Many physiological events require an accurate timing signal, usually generated by neural networks called central pattern generators (CPGs). On the other hand, properties of neurons and neural networks (e.g. time constants of neurons and weights of network connections) alter with time, resulting in gradual changes in timing of such networks. Recently, a synaptic weight adjustment mechanism has b...
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Many physiological events require an accurate timing signal, usually generated by neural networks called central pattern generators (CPGs). On the other hand, properties of neurons and neural networks (e.g. time constants of neurons and weights of network connections) alter with time, resulting in gradual changes in timing of such networks. Recently, a synaptic weight adjustment mechanism has b...
متن کاملRequirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity.
Spike timing-dependent synaptic plasticity (STDP) plays an important role in neural development and information processing in the brain; however, the mechanism by which spike timing information is encoded into STDP remains unclear. Here, we show that a novel allosteric kinetics of NMDA receptors (NMDARs) is required for STDP. We developed a detailed biophysical model of STDP and found that the ...
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عنوان ژورنال:
- Neuron
دوره 32 شماره
صفحات -
تاریخ انتشار 2001