Trichloroethanol and Trichloroacetic Acid in Urine
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چکیده
When trichloroacetic acid (TCA) and trichloroethanol (TCE) in the urine of human subjects, rabbits, rats, and guinea-pigs were determined by Seto and Schultze's (I956) method, the recovery of TCE, added to urine, varied widely from 8i 3% in guinea-pig urine to i6-2% in rat urine. To obtain the maximum recovery of added TCE, Seto and Schultze's method was further modified to give satisfactory results (recovery rate of 95.9 to 98-5%) when applied to human urine as well as to the urine of the above species of animals. Urine samples from human subjects as well as from rats exposed to trichloroethylene were analysed by this modified method. The results showed that the ratio of TCE to TCA varies as a function of environmental trichloroethylene concentration, indicating that the determination of total trichlorocompounds gives a better index of trichloroethylene exposure than does the determination of TCA alone.
منابع مشابه
Excretion of organic chlorine compounds in the urine of persons exposed to vapours of trichloroethylene and tetrachloroethylene.
Ogata, M., Yoshiko, T., and Tomokuni, K. (1971). Brit. J. industr. Med., 28, 386-391. Excretion of organic chlorine compounds in the urine of persons exposed to vapours of trichloroethylene and tetrachloroethylene. Male volunteers were exposed to 170 p.p.m. of trichloroethylene vapour either for 3 hours or for 7 hours with one break of 1 hour; or to 87 p.p.m. of tetrachloroethylene vapour for 3...
متن کاملDifferences in urinary trichloroethylene metabolites of animals.
Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg) was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats ...
متن کاملTrichloroethylene Toxicological overview
Trichloroethylene is readily absorbed following exposure by inhalation or ingestion and to some extent following skin contact Following absorption trichloroethylene is distributed throughout the body Trichloroethylene undergoes metabolism via an oxidative pathway The main metabolites are trichloroethanol, trichloroethanol-glucuronide and trichloroacetic acid Trichloroethylene is excre...
متن کاملA simple method for the quantitative analysis of urinary trichloroethanol and trichloroacetic acid as an index of trichloroethylene exposure.
Ogata, M., Takatsuka, Y., and Tomokuni, K. (1970). Brit. J. industr. Med., 27, 378-381. A simple method for the quantitative analysis ofurinary trichloroethanol and trichloroacetic acid as an index of trichloroethylene exposure. A simple method of estimating trichloroethanol and trichloroacetic acid in the urine of workers exposed to trichloroethylene is described. The glucuronide of trichloroe...
متن کاملUrinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene.
Ikeda, M., Ohtsuji, H., Imamura, T., and Komoike, Y. (1972). Brit. J. industr. Med., 29, 328-333. Urinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene. To investigate the relation between trichloroethylene and tetrachloroethylene concentrations in working environments and metabolite conce...
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