A Shear Rig for the Study of Mechanotransduction in Chondrocyte - Agarose Constructs: Analysis of Local Strain Fields

mmer Bioengineering Conference, June 25-29, Sonesta Beach Resort in Key Biscayne, Florida in synovial joints is exposed to compressive normal activity. These mechanical signals are and homeostasis of the tissue. Consequently ng has been proposed within a tissue stimulation of isolated cells seeded within 3D antation. However, the mechanotransduction ch cells are able to sense and respond to thin 3D scaffolds are poorly understood. A groups have utilised a well characterised odel to examine the influence of compressive lism and the associated intracellular signalling ntrast the effect of shear strain has received ble due to the complex test rigs required [3-4]. e development and characterisation of a new the application of static or cyclic shear strain ts.