Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human A (1–42): Implications for Alzheimer’s disease
نویسندگان
چکیده
a Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, 121 Chemistry-Physics Building, University of Kentucky, Lexington, KY 40506-0055, USA b Core Proteomics Laboratory, University of Kentucky, Lexington, KY, USA c Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA d Department of Pharmacology and Toxicology, University of Louisville School of Medicine and VAMC, Louisville, KY, USA e Kidney Disease Program and Proteomics Core Laboratory, University of Louisville School of Medicine and VAMC, Louisville, KY, USA f Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
منابع مشابه
Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease.
Protein oxidation has been shown to lead to loss of protein function, increased protein aggregation, decreased protein turnover, decreased membrane fluidity, altered cellular redox poteintial, loss of Ca2+ homeostaisis, and cell death. There is increasing evidence that protein oxidation is involved in the pathogenesis of Alzheimer's disease and amyloid beta-peptide (1-42) has been implicated as...
متن کاملOxidative stress precedes fibrillar deposition of Alzheimer’s disease amyloid -peptide (1–42) in a transgenic Caenorhabditis elegans model
Alzheimer’s disease is a progressive, neurodegenerative disorder characterized by senile plaques and neurofibrillary components. A (1–42) is a principal component of senile plaques and is thought to be central to the pathogenesis of the disease. The Alzheimer’s disease brain is under significant oxidative stress, and the A (1–42) peptide is known to cause oxidative stress in vitro. One controve...
متن کاملTocotrienol Modulates the Expression of Proteins in Oxidative Stress-Induced Caenorhabditis Elegans
Objective: Oxidative stress that damages proteins result in aging and age related diseases. The aim of this study is to determine the effect of tocotrienol rich fraction (TRF) on the expression of proteins in oxidative stress-induced caenohabditis elegans (C.elegans) which has homologous genes to humans. Methods: The worms were treated with TRF prior to, after and continuously in separate group...
متن کاملNicotine affects protein complex rearrangement in Caenorhabditis elegans cells.
Nicotine may affect cell function by rearranging protein complexes. We aimed to determine nicotine-induced alterations of protein complexes in Caenorhabditis elegans (C. elegans) cells, thereby revealing links between nicotine exposure and protein complex modulation. We compared the proteomic alterations induced by low and high nicotine concentrations (0.01 mM and 1 mM) with the control (no nic...
متن کاملProteomic analysis of mitochondria from Caenorhabditis elegans.
Mitochondria play essential roles in cell physiological processes including energy production, metabolism, ion homeostasis, cell growth, aging and apoptosis. Proteomic strategies have been applied to the study of mitochondria since 1998; these studies have yielded decisive information about the diverse physiological functions of the organelle. As an ideal model biological system, the nematode C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005