Ca influx through the osteoclastic plasma membrane ryanodine receptor
نویسندگان
چکیده
BALJIT S. MOONGA,1 SUN LI,1* JAMEEL IQBAL,1* ROBERT DAVIDSON,2 VIJAI S. SHANKAR,3 PETER J. R. BEVIS,1 ANGELA INZERILLO,1 ETSUKO ABE,1 CHRISTOPHER L.-H. HUANG,3 AND MONE ZAIDI1 1Mount Sinai Bone Program, Departments of Medicine and Geriatrics, Mount Sinai School of Medicine, and the Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, New York 10029; 2Division of Basic Sciences, New York University Dental School, New York, New York 10010; and 3Department of Physiology, Cambridge University, Cambridge CB2 3EG, United Kingdom
منابع مشابه
Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor.
We predict that the type 2 ryanodine receptor isoform (RyR-2) located in the osteoclastic membrane functions as a Ca(2+) influx channel and as a divalent cation (Ca(2+)) sensor. Cytosolic Ca(2+) measurements revealed Ca(2+) influx in osteoclasts at depolarized membrane potentials. The cytosolic Ca(2+) change was, as expected, not seen in Ca(2+)-free medium and was blocked by the RyR modulator r...
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تاریخ انتشار 2002