Is the Balloon Dilation Duration in Endoscopic Papillary Balloon Dilation (EPBD) Related to the Occurrence of Post-EPBD Pancreatitis?
نویسنده
چکیده
papillary balloon dilation (EPBD) was proposed as an alternative to endoscopic sphincterotomy (EST) for opening the bile duct orifice to allow stone extraction with functional preservation of the biliary sphincter. Since its introduction in 1982, 1 EPBD has been widely performed because it is associated with lower bleeding and perforation risks compared to EST. 2-6 However, EPBD is more likely to cause pancreatitis than EST, resulting in an increased mortality rate. 7,8 Therefore, EPBD is reserved for selective patients with a bleeding diathesis or altered anatomy, especially in Western countries. The reported incidence of post-EPBD pancreatitis varies greatly, ranging from 0% to 15.4%. This disparity may be explained by differences in the stone size, bile duct size, balloon diameter, and balloon dilation duration (BDD). Although the mechanism is unknown, post-EPBD pancreatitis has been associated with papillary edema or spasm resulting from balloon dilation and papillary trauma during stone extraction through an insufficiently dilated sphincter. Therefore, papil-lary injury resulting in increased post-EPBD pancreatitis may frequently occur in cases with relatively large stones in small bile ducts and balloon diameters larger than the stone size or 6 bile duct diameter. BDD was found to correlate with post-EPBD pancreatitis in previous studies, although the results were conflicting. In a prospective randomized trial, 14 the risk of pancreatitis was higher with a 1-minute BDD (15.1%, 13/86) than with a 5-minute BDD (4.8%, 4/84; p=0.038). In a systemic review of ran-domized trials that compared EPBD and EST, 15 short EPBD (≤1 minute) had a higher risk for pancreatitis (odds ratio [OR], 3.87; 95% confidence interval [CI], 1.08 to 13.84) compared to EST, but long EPBD (>1 minute) did not pose a higher risk than EST (OR, 1.14; 95% CI, 0.56 to 2.35). A longer BDD may achieve greater loosening of the sphincter of Oddi and cause less papillary damage during stone extraction, resulting in a lower pancreatitis rate. In contrast, however, an initial 2-minute BDD was modified to 15 seconds during the later period of a retrospective study. 16 A lesser tendency toward post-EPBD pancreatitis was observed in the modified group (4%, 13/324) relative to the initial group (7.4%, 24/324; p=0.063). A shorter BDD may be less traumatic to the papilla, thus reducing post-EPBD pancreatitis. Bang et al. 17 evaluated the risk of pancreatitis after EPBD with a 20-or 60-second BDD in patients with relatively small bile duct stones (≤12 mm) while using balloon diameters …
منابع مشابه
Dilation Time in Endoscopic Papillary Balloon Dilation for Common Bile Duct Stones
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BACKGROUND/AIMS Endoscopic papillary balloon dilation (EPBD) has been advocated as an alternative therapy to endoscopic sphincterotomy for the treatment of common bile duct (CBD) stones. However, there is no established consensus on the optimal balloon dilation duration (BDD). We prospectively evaluated the efficacy and post-endoscopic retrograde cholangiopancreatography (ERCP) complications be...
متن کاملMulticenter retrospective and comparative study of 5-minute versus 15-second endoscopic papillary balloon dilation for removal of bile duct stones
BACKGROUND AND STUDY AIMS Endoscopic papillary balloon dilation (EPBD) is a method of bile duct stone removal that has a better long-term outcome but a high risk of post-ERCP pancreatitis (PEP). Recent studies have suggested that 5-minute EPBD can reduce the incidence of PEP. This study aimed to examine the safety and effectiveness of longer duration EPBD compared with shorter duration EPBD (5...
متن کاملCurrent status of endoscopic papillary balloon dilation for the treatment of bile duct stones
BACKGROUND/PURPOSE While endoscopic sphincterotomy (EST) is performed worldwide for the removal of common bile duct stones, many biliary endoscopists hesitate to regard endoscopic papillary balloon dilation (EPBD) as a standard procedure for treatment. Therefore, the aim of this review is to re-evaluate the status of EPBD for the treatment of common bile duct stones. RESULTS A major benefit o...
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Background. No study investigated the efficacy and safety of endoscopic papillary balloon dilation (EPBD) for the treatment of acute biliary pancreatitis (ABP). Method. We retrospectively reviewed the effects of EPBD on patients with ABP from February 2003 to December 2012. The general data, findings of image studies, details of the procedure, and outcomes after EPBD were analyzed. Result. Tota...
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عنوان ژورنال:
دوره 48 شماره
صفحات -
تاریخ انتشار 2015