Involvement of PAF metabolism in anaphylaxis and prevention by Rush-SOTI

Background Allergy is a critical problem of public health in developed countries. Anaphylaxis is a rapid allergic response with symptoms such as urticarial, itching, diarrhea, and even death. Since allergy is caused by the failure of tolerance induction to exogenous antigens, its establishment of tolerance is a fundamental therapy for allergic diseases. Oral tolerance is a physiological way to actively induce unresponsiveness to food antigens. However, oral immunotherapy using antigens occasionally fails to induce complete tolerance in patients that hinder the development of the therapy.