Effect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken.

BERGER,LAWRENCE,T'SAIFANY~~ANDALEXANDER B. GUTMAN. Efect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken. Am. J. Physiol. rg8(3) : 575-580. 1960. -In 43 chickens, the mean Cinulin was 4.7 + I .8 ml/min. (I .8 =t 0.8 ml/kg/ min.), mean C urate 29.0 rt 14.9 ml/min. (I 1.3 =t 6.0 ml/kg/ min.) and mean Turate 1.30 zt 0.69 mg/min. (0.48 & 0.24 mg/kg/ min.). Tubular secretion accounted for a mean of 81 yO of the total urinary urate. Probenecid, sulfinpyrazone, zoxazolamine and high dosages of phenylbutazone, all uricosuric in man, reduced urate excretion in the chicken, apparently by suppressing tubular secretion of urate; C&n also was reduced. Salicylate, in doses uricosuric in man, had no effect on chicken urate excretion. Pyrazinamide and sodium rlactate, agents which decrease urate excretion in man, did not alter urate excretion in the chicken. PAH loading experiments demonstrated that as TrAn increased, Turate decreased. These latter findings suggest competition of urate and PAH for renal tubular transport in the chicken.