Progesterone Receptor Isoforms, PRA and PRB, Differentially Regulate Expression of the Breast Cancer Resistance Protein (BCRP) in Human Placental Choriocarcinoma BeWo Cells
نویسندگان
چکیده
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (H.W., E.-W.L., L.Z., J.D.U., Q.M.), and Department of Life Science and Biotechnology, College of Natural Science, Dongeui University, Busan, Korea (E.-W.L.), and Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada (P.C.K.L.), and University of Maryland Greenebaum Cancer Center and School of Medicine, and the Baltimore VA Medical Center, Baltimore, Maryland (D.D.R.). Molecular Pharmacology Fast Forward. Published on November 27, 2007 as doi:10.1124/mol.107.041087
منابع مشابه
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cells.
Breast cancer resistance protein (BCRP) plays a significant role in drug disposition and in conferring multidrug resistance in cancer cells. Previous studies have shown that steroid hormones such as 17beta-estradiol and progesterone can affect BCRP expression in cancer cells. In this study, we investigated the molecular mechanism by which BCRP expression in human placental choriocarcinoma BeWo ...
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The breast cancer resistance protein (BCRP) is abundant in the placenta and protects the fetus by limiting placental drug penetration. We hypothesize that pregnancyspecific hormones regulate BCRP expression. Hence, we examined the effects of progesterone (P4) and 17β-estradiol (E2) on BCRP expression in the human placental BeWo cells. P4 and E2 significantly increased and decreased BCRP protein...
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Glyburide is frequently used to treat gestational diabetes owing to its low fetal accumulation resulting from placental efflux by the breast cancer resistance protein (BCRP)/ABCG2 transporter. Here we sought to determine how exposure to the dietary phytoestrogen genistein and expression of a loss-of-function polymorphism in the ABCG2 gene (C421A) impacted the transport of glyburide by BCRP usin...
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Progesterone receptor (PR) and progestins affect mammary tumorigenesis; however, the relative contributions of PR isoforms A and B (PRA and PRB, respectively) in cancer cell migration remains elusive. By using a bi-inducible MDA-MB-231 breast cancer cell line expressing PRA and/or PRB, we analyzed the effect of conditional PR isoform expression. Surprisingly, unliganded PRB but not PRA strongly...
متن کاملRegulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells.
The breast cancer resistance protein (BCRP) is abundant in the placenta and protects the fetus by limiting placental drug penetration. We hypothesize that pregnancy-specific hormones regulate BCRP expression. Hence, we examined the effects of progesterone (P4) and 17beta-estradiol (E2) on BCRP expression in the human placental BeWo cells. P4 and E2 significantly increased and decreased BCRP pro...
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تاریخ انتشار 2007