Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca channel and the type 1 ryanodine receptor

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298; Cardiology Division, Department of Medicine, and Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver–Anschutz Medical Campus, Aurora, CO 80045; Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 8380453; Malignant Hyperthermia Investigation Unit, Leeds Institute of Molecular Medicine, St. James’s University Hospital, Leeds LS9 7TF, United Kingdom; Department of Molecular Biosciences, Center for Children’s Environmental Health and Disease Prevention, School of Veterinary Medicine, University of California, Davis, CA 95616; and Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093