Cycloheximide production by Streptomyces griseus: alleviation of end-product inhibition by dialysis-extraction fermentation.
نویسنده
چکیده
The use of dialysis fermentation with the continuous extraction of the dialysate has resulted in a twofold increase in the cycloheximide titer due to relief from product inhibition. Continuous extraction of the dialysate has eliminated the necessity for large reservoir volumes of fermentation medium normally used in dialysis fermentation. The apparatus used in this procedure is described.
منابع مشابه
Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.
Cycloheximide accumulation in a fermentation medium has been shown to be the product of the balance between synthesis and degradation of this antibiotic. Glucose has been shown to prevent cycloheximide degradation. Cycloheximide has been shown to interfere with its own synthesis probably due to feedback inhibition. Approaches for increasing cycloheximide titers in the light of these findings ar...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 7 6 شماره
صفحات -
تاریخ انتشار 1975