ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation.
نویسندگان
چکیده
Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
منابع مشابه
Insights Into the Role of Monocyte Lipid Efflux in HDL Formation and Inflammation
Studies with ATP-binding cassette transporter (ABCA1)–deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on a...
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Macrophages are incapable of limiting the uptake of lipids and therefore rely on cholesterol efflux mechanisms for maintaining cellular cholesterol homeostasis. Important mediators of macrophage cholesterol efflux are ABCA1, which mediates the efflux of cholesterol to lipid-poor apoAI, and SR-BI that promotes efflux to mature HDL. To get further insight into the putative synergistic roles of AB...
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عنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 23 6 شماره
صفحات -
تاریخ انتشار 2003