Studies on Tuberculin Fever

نویسندگان

  • William J. Hall
  • Lorraine Francis
  • Elisha Atkins
چکیده

In a search for the source of the circulating endogenous pyrogen (EP) that mediates tuberculin-induced fever, tuberculin was incubated in vitro with various tissues of rabbits sensitized by intravenous infection with BCG. Evidence was obtained that tuberculin specifically stimulates cells in the blood of sensitized rabbits to generate pyrogen in vitro, whereas both lymph node and spleen cells from the same donors were inactive. Since normal blood cells, incubated in plasma of sensitized donors, were similarly activated, it is postulated that circulating antibodies play a role in sensitizing cells (presumably granulocytes) to release pyrogen on contact with tuberculin) both in vitro and in vivo. Release of endogenous pyrogen in vitro may be a sensitive means of detecting immunologic reactions between antigen and specifically sensitized blood cells-in other allergic states accompanied by fever.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

STUDIES ON TUBERCULIN FEVER* IV. THE PASSIVE TRANSFER OF REACTIVITY WITH VARIOUS TlSSlmS OF SENSITIZED DONOR RABBITS

Fever is a hallmark of tuberculin hypersensitivity. Ever since the dassic papers of von Pirquet (1) and the clinico-pathologic observations of Rich (2), fever has been recognized as a cardinal sign of tuberculous infection. The actual events, however, that lead to elevated body temperature in this disease have remained obscure. Many manifestations of tuberculin hypersensitivity, like the skin t...

متن کامل

Unusual etiology of cystic lesions in the lung.

57 year old man was admitted because of cystic lesions on his chest x-ray film (Fig 1). Eight months earlier, transitional cell carcinoma of the bladder, grade 3, was diagnosed, for which he received local irradiation, followed by radical cystectomy. There was no evidence of metastatic disease. On admission, the patient denied increased cough, sputum production, dyspnea, fever, weight loss, hem...

متن کامل

Cat-Scratch Disease In Adult Hospitalized For Prolonged-Fever Associated With Multiple Lymphadenopathies and Weight Loss

We report a 19-year-old patient with a Cat-scratch disease presenting three months continuous alteration of the general condition, including prolonged-fever, anorexia, asthenia, weight loss associated with adenitis and multiple thoracic-abdominal adenopathies, leukocytosis with neutrophil polynuclear predominance, and increased of C-reactive protein. The serologies of toxoplasmosis, infectious ...

متن کامل

Prognostic factors in 454 cases of Hodgkin's disease.

between 1922 and 1963 was carried out. Clinical stage, age, sex, histolÃ3gica! type, presence of or absence of loss of weight, fever, night sweats, erythrocyte sedimentation rate, and red cell, granulocyte, and lymphocyte blood counts all have significant correlation with survival. Most of these factors are themselves interrelated. Statistical studies were carried out in order to evaluate the i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 122  شماره 

صفحات  -

تاریخ انتشار 1959