The haemostatic and hemodynamic effects of Epinephrine in septoplasty

The aimed of this study was to compare 2 different concentration of adrenaline (epinephrine) on patients’ hemodynamic effect and intra-operative bleeding. A prospective randomized double blind control study using 2 different concentrations of epinephrine was designed to observe hemodynamic and haemostatic changes during septoplasty and to observe any cardiac complications. Sixty patients underwent elective septoplasty, age range between 21 and 70 years were enrolled in this study, started March 2013 to June 2014 and all done in Muhayl Hospital, Aseer Region, Saudi Arabia by the same surgeon using the same technique and same anesthetist. Patients randomized to group 1 received 1:100 000 epinephrine (n=30patients), and patients randomized to group 2 received 1:200 000 epinephrine (n=30patients). Data of the patients’ parameters were collected during the procedure: HR, systolic (SBP) and diastolic (DBP) and mean arterial pressure (MAP). These parameters were monitored by the anesthesiologist throughout the procedure and were repeated at 1-minute intervals for 5 minutes. Significant hemodynamic fluctuations were noted in group 1. The increase was found to be significant (P<.001) in the first and second and third minutes after injection and decreased to baseline level by the 4th and 5th minutes, while in group 2 who received lidocaine, 2%, 1:200 000 epinephrine no changes noted. No statistical difference in the 2 groups was observed of intra-operative bleeding (P>.05). The baseline hemodynamic parameters were similar in both groups (Table 1). Table 2 summarizes the hemodynamic changes after injection of epinephrine. We concluded that the use of adrenaline 1:200,000 not cause hemodynamic effect or increase in intra-operative bleeding. [Ali Maeed Al-Shehri. The haemostatic and hemodynamic effects of Epinephrine in septoplasty. Life Sci J 2015;12(8):7-9]. (ISSN:1097-8135). http://www.lifesciencesite.com. 2